Cancer-Ml: Modeling Fitness of Unregulated RAS Mutants using Computational Mutagenesis and Machine Learning

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

scour modeling piles of kambuzia industrial city bridge using hec-ras and artificial neural network

today, scouring is one of the important topics in the river and coastal engineering so that the most destruction in the bridges is occurred due to this phenomenon. whereas the bridges are assumed as the most important connecting structures in the communications roads in the country and their importance is doubled while floodwater, thus exact design and maintenance thereof is very crucial. f...

the relationship between using language learning strategies, learners’ optimism, educational status, duration of learning and demotivation

with the growth of more humanistic approaches towards teaching foreign languages, more emphasis has been put on learners’ feelings, emotions and individual differences. one of the issues in teaching and learning english as a foreign language is demotivation. the purpose of this study was to investigate the relationship between the components of language learning strategies, optimism, duration o...

15 صفحه اول

Accurate prediction of stability changes in protein mutants by combining machine learning with structure based computational mutagenesis

MOTIVATION Accurate predictive models for the impact of single amino acid substitutions on protein stability provide insight into protein structure and function. Such models are also valuable for the design and engineering of new proteins. Previously described methods have utilized properties of protein sequence or structure to predict the free energy change of mutants due to thermal (DeltaDelt...

متن کامل

Machine learning methods in computational cancer biology

Molecular data from cancer tumours is characterized by the fact that the number of measured features is in the tens of thousands, while the number of samples is a few hundred at best. This mismatch necessitates the development of new algorithms for sparse regression and sparse classification with an eye towards cancer applications. Another aspect of biological data, which has no analogue in eng...

متن کامل

Machine learning algorithms in air quality modeling

Modern studies in the field of environment science and engineering show that deterministic models struggle to capture the relationship between the concentration of atmospheric pollutants and their emission sources. The recent advances in statistical modeling based on machine learning approaches have emerged as solution to tackle these issues. It is a fact that, input variable type largely affec...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Biophysical Journal

سال: 2019

ISSN: 0006-3495

DOI: 10.1016/j.bpj.2018.11.3015